It is a neuromuscular disease causing a gradual muscle weakness on the hindlimb and back, which is manifested by poor coordination of movements, cramped and asymmetric walking, or incontinence. The disease affects a wide range of dog breeds (described in more than 100 breeds) and start to develope at middle or upper age. Unfortunately, the disease is untreatable, it is gradually deteriorating, and after 3-5 years from the first manifestation of the disease, a death frequently occurs due to general weakness and paralysis of the respiratory muscles.
Tested gene and sequence: SOD1, part of exon 2
Breed: All breeds
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